Sutures and Wound Repair/ General Surgery (ABSA) Practice Test

What is a potential consequence of adrenal steroid therapy after hypophysectomy?

1. Increased metabolism

2. Dehydration

3. Diabetes insipidus

4. All of the above

The correct answer is: Diabetes insipidus

Adrenal steroid therapy after hypophysectomy can lead to a disturbance in the balance of hormones within the body due to the removal of the pituitary gland, which is essential for regulating various endocrine functions. One of the significant potential consequences is the development of diabetes insipidus, a condition characterized by an inability to concentrate urine, leading to excessive urination and thirst. After a hypophysectomy, especially if the posterior pituitary is involved, the secretion of antidiuretic hormone (ADH) can be disrupted. This hormone plays a crucial role in water retention by the kidneys. Without adequate levels of ADH, the kidneys excrete large volumes of dilute urine, which precipitates diabetes insipidus. Increased metabolism and dehydration can potentially be consequences of hormonal imbalances associated with adrenal steroid therapy; however, these issues primarily arise from the steroids influencing metabolic rates and fluid balance, rather than being direct results of the pituitary being removed. Therefore, although they are possible effects of hormonal therapy, they are not as specific to adrenal steroid therapy post-hypophysectomy as diabetes insipidus is. Hence, the focus on diabetes insipidus as the primary concern showcases its direct link to the changes induced by the surgery and